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Article

A Whole-Cell Catalytic System for Equol Production Based on Daidzein Reductase Engineering.

Molecules (Basel, Switzerland) - 18 Feb 2026

Li Bing-Juan, Zhuo Jiao-Jiao, Tian Meng-Ran, Meng Dan, Li Hong-Yan

Abstract excerpt

As an isoflavone metabolite with diverse physiological activities, the development of efficient and sustainable manufacturing technologies for (S)-equol holds significant importance. This study focuses on the semi-rational design of daidzein reductase (DZNR), the first key enzyme in the (S)-equol biotransformation pathway. Through multiple sequence alignment and three-dimensional structural analysis, two critical...

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Identifiers

PMID: 41752488
DOI: 10.3390/molecules31040711
PMCID: PMC12943075

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A Whole-Cell Catalytic System for Equol Production Based on Daidzein Reductase Engineering.PMID 41752488Read ↗

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