Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.

PloS one - 1 Jan 2012

Chang Yu-Hsin, Lee Chung-Pei, Su Mei-Tzu, Wang Jiin-Tarng, Chen Jen-Yang, Lin Su-Fang, Tsai Ching-Hwa, Hsieh Min-Jei, Takada Kenzo, Chen Mei-Ru

Abstract excerpt

Epstein-Barr virus (EBV) induces an uncoordinated S-phase-like cellular environment coupled with multiple prophase-like events in cells replicating the virus. The EBV encoded Ser/Thr kinase BGLF4 has been shown to induce premature chromosome condensation through activation of condensin and topoisomerase II and reorganization of the nuclear lamina to facilitate the nuclear egress of nucleocapsids in a pathway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2 Protein Kinase
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to G1 Phase

Share to Herpesvirus 4, Human

Share to Micronuclei, Chromosome-Defective

Share to Retinoblastoma Protein

Share to S Phase

Share to Thymidine

Source

Open in PubMed Open full text

Identifiers

PMID: 22768064
DOI: 10.1371/journal.pone.0039217
PMCID: PMC3387188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.PMID 22768064Read ↗

Identification of Herpesvirus Proteins That Contribute to G 1 /S ArrestSemantic proximity Read ↗

S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene TranscriptionSemantic proximity Read ↗

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethalitySemantic proximity Read ↗

SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.Semantic proximity Read ↗

Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.Semantic proximity Read ↗

EBP2 Plays a Key Role in Epstein-Barr Virus Mitotic Segregation and Is Regulated by Aurora Family KinasesSemantic proximity Read ↗

Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis.Semantic proximity Read ↗

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear LocalizationSemantic proximity Read ↗

Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest.Semantic proximity Read ↗

The Epstein-Barr virus protein kinase BGLF4 and the exonuclease BGLF5 have opposite effects on the regulation of viral protein production.Semantic proximity Read ↗

Inhibition of S-Phase Cyclin-Dependent Kinase Activity Blocks Expression of Epstein-Barr Virus Immediate-Early and Early Genes, Preventing Viral Lytic ReplicationSemantic proximity Read ↗

KLF4 suppresses transformation of pre-B cells by ABL oncogenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.