Article
SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.
Journal of virology - 1 May 2012
Li Renfeng, Wang Leyao, Liao Gangling, Guzzo Catherine M, Matunis Michael J, Zhu Heng, Hayward S Diane
Abstract excerpt
An Epstein-Barr virus (EBV) protein microarray was used to screen for proteins binding noncovalently to the small ubiquitin-like modifier SUMO2. Among the 11 SUMO binding proteins identified was the conserved protein kinase BGLF4. The mutation of potential SUMO interaction motifs (SIMs) in BGLF4 identified N- and C-terminal SIMs. The mutation of both SIMs changed the intracellular localization of BGLF4 from...
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