Article
Arrhythmogenic right ventricular cardiomyopathy: new insights into disease mechanisms and diagnosis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Dec 2009
Saffitz Jeffrey E, Asimaki Angeliki, Huang Hayden
Abstract excerpt
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle disorder characterized by the early occurrence of serious tachyarrhythmias often out of proportion to the extent of structural changes and contractile derangement. Approximately 40% of patients with ARVC have one or more mutations in genes encoding proteins in desmosomes, intercellular adhesion junctions which, in cardiac myocytes,...
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