Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer.

doi:10.18632/oncotarget.6844

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Article

Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer.

Oncotarget - 16 Feb 2016

Wen Feng, Liu Yongmei, Wang Wei, Li Meng, Guo Fuchun, Sang Yaxiong, Qin Qing, Wang Yongsheng, Li Qiu

Abstract excerpt

Toll-like receptors (TLRs)/NF-κB activation stimulated by lipopolysaccharide (LPS) was associated with diverse biological response in colon cancer, but the underlying mechanism was largely unknown. In the current study, we reported cell proliferation was elevated in adenomatous polyposis coli (APC) mutated- and APC knockdown cell lines, while the proliferation was inhibited in APC wild-type cell lines. Besides,...

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PMID: 26760960
DOI: 10.18632/oncotarget.6844
PMCID: PMC4884952

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