Article
TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients.
Cancer biomarkers : section A of Disease markers - 1 Jan 2022
de Pádua Covas Lage Luís Alberto, Barreto Guilherme Carneiro, Culler Hebert Fabricio, Cavalcante Jéssica Billar, de Oliveira Alves Lucas Bassolli, Nardinelli Luciana, Bendit Israel, Zerbini Maria Cláudia Nogueira, Rocha Vanderson, Pereira Juliana
Abstract excerpt
INTRODUCTION: Nodal peripheral T-cell lymphomas [nPTCL] constitute a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena involving genes that control DNA-methylation and histone deacetylation play a central role in their pathogenesis. However, the mutational landscape involving epigenetic regulators has never been reported in Latin American...
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