Article
MuSiC: identifying mutational significance in cancer genomes.
Genome research - 1 Aug 2012
Dees Nathan D, Zhang Qunyuan, Kandoth Cyriac, Wendl Michael C, Schierding William, Koboldt Daniel C, Mooney Thomas B, Callaway Matthew B, Dooling David, Mardis Elaine R, Wilson Richard K, Ding Li
Abstract excerpt
Massively parallel sequencing technology and the associated rapidly decreasing sequencing costs have enabled systemic analyses of somatic mutations in large cohorts of cancer cases. Here we introduce a comprehensive mutational analysis pipeline that uses standardized sequence-based inputs along with multiple types of clinical data to establish correlations among mutation sites, affected genes and pathways, and to...
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