Article
High-resolution structures of Neotermes koshunensis β-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates.
Acta crystallographica. Section D, Biological crystallography - 1 Jul 2012
Jeng Wen-Yih, Wang Nai-Chen, Lin Cheng-Tse, Chang Wei-Jung, Liu Chia-I, Wang Andrew H-J
Abstract excerpt
NkBgl, a β-glucosidase from Neotermes koshunensis, is a β-retaining glycosyl hydrolase family 1 enzyme that cleaves β-glucosidic linkages in disaccharide or glucose-substituted molecules. β-Glucosidases have been widely used in several applications. For example, mutagenesis of the attacking nucleophile in β-glucosidase has been conducted to convert it into a glycosynthase for the synthesis of oligosaccharides....
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