Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.

doi:10.1371/journal.pone.0038663

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Article

Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.

PloS one - 1 Jan 2012

Hager Jörg, Kamatani Yoichiro, Cazier Jean-Baptiste, Youhanna Sonia, Ghassibe-Sabbagh Michella, Platt Daniel E, Abchee Antoine B, Romanos Jihane, Khazen Georges, Othman Raed, Badro Danielle A, Haber Marc, Salloum Angelique K, Douaihy Bouchra, Shasha Nabil, Kabbani Samer, Sbeite Hana, Chammas Elie, el Bayeh Hamid, Rousseau Francis, Zelenika Diana, Gut Ivo, Lathrop Mark, Farrall Martin, Gauguier Dominique, Zalloua Pierre A

Abstract excerpt

The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are a crucial step in understanding global CAD pathophysiology. In this study, we report a GWAS on...

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Identifiers

PMID: 22745674
DOI: 10.1371/journal.pone.0038663
PMCID: PMC3380020

Genes

CAD
PHACTR1

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