Article
ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2012
Sukov William R, Hodge Jennelle C, Lohse Christine M, Akre Monica K, Leibovich Bradley C, Thompson R Houston, Cheville John C
Abstract excerpt
Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types. Recently, the ALK protein inhibitor crizotinib was shown to be an effective therapy in patients with ALK-rearranged non-small cell lung cancer. The goal of this study was to determine the frequency...
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