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Article

ALK -Rearranged Renal Cell Carcinoma : Morphologic Spectrum and Genomic Landscape From a Multi-Institutional Cohort of 16 Cases.

The American journal of surgical pathology - 1 May 2026

Lobo Anandi, Akgul Mahmut, Sangoi Ankur R, Al-Obaidy Khaleel I, Acosta Andres M, Kandukuri Shivani R, Kapoor Rahul, Mishra Sourav K, Jha Shilpy, Kaushal Seema, Satturwar Swati, Osunkoya Adeboye O, Parwani Anil V, Dhillon Jasreman, Jain Ekta, Williamson Sean R, Shah Rajal B, Mohanty Sambit K, Cheng Liang

Abstract excerpt

Due to its heterogeneous morphology and its rarity, anaplastic lymphoma kinase gene-rearranged renal cell carcinoma ( ALK RCC) is a diagnostically challenging entity, often leading to labelling these tumors as RCC, not otherwise classified. This may have clinical and managerial implications, given that patients with ALK oncogene rearrangement may benefit from ALK -inhibitors. Therefore, we attempted to elucidate...

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Topics

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Share to Anaplastic Lymphoma Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Renal Cell

Share to Gene Rearrangement

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 41790060
DOI: 10.1097/PAS.0000000000002525

Genes

ALK
AMACR
EML4
FH
KRT7
PAX8
SLIT1
TPM1
TPM3
VCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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