Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl resistance.

doi:10.1002/cm.970220304

Back to search

Article

Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl resistance.

Cell motility and the cytoskeleton - 1 Jan 1992

Jung M K, Wilder I B, Oakley B R

Abstract excerpt

We report the cloning and sequencing of 18 mutant alleles of the benA, beta-tubulin gene of Aspergillus nidulans that confer resistance to the benzimidazole antifungal, antimicrotubule compounds benomyl, carbendazim, nocodazole, and thiabendazole. In 12 cases, amino acid 6 was changed from histid...

Topics

Alleles
Amino Acids
Animals
Aspergillus nidulans
Benomyl
Benzimidazoles
Binding Sites
Carbamates
Drug Resistance, Microbial
Mutagenesis, Site-Directed
Mutation
Nocodazole
Thiabendazole
Tubulin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.