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Article

Transformation of a transposon into a derived prolactin promoter with function during human pregnancy

25 Jun 2012

Abstract excerpt

Transposable elements (TEs) are known to provide DNA for host regulatory functions, but the mechanisms underlying the transformation of TEs into cis-regulatory elements are unclear. In humans two TEs--MER20 and MER39--contribute the enhancer/promoter for decidual prolactin (dPRL), which is dramatically induced during pregnancy. We show that evolution of the strong human dPRL promoter was a multistep process that...

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PMID: 22733751
DOI: 10.1073/pnas.1118566109

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