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Article

An alternative pathway in colorectal carcinogenesis based on the mismatch repair system and p53 expression in Korean patients with sporadic colorectal cancer.

Annals of surgical oncology - 1 Nov 2013

Kim Hyoung Ran, Kim Hee Cheol, Yun Hae-Ran, Kim Seok Hyung, Park Cheol Keun, Cho Yong Beom, Yun Seong Hyeon, Lee Woo Yong, Chun Ho-Kyung

Abstract excerpt

PURPOSE: Microsatellite instability (MSI) and chromosomal instability are main mechanisms underlying colorectal carcinogenesis. We determined the features and prognosis of colorectal cancer based on MSI including mismatch repair genes and expression of p53. METHODS: Between 1999 and 2008, a total of 2,649 colorectal cancer patients were analyzed using a prospective database. A mismatch repair defect (MMR-D) was...

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PMID: 22732839
DOI: 10.1245/s10434-012-2455-7

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