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Article

The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance.

Journal of hepatology - 1 Oct 2012

Shlomai Amir, Rechtman Maya Mouler, Burdelova Ela Olga, Zilberberg Alona, Hoffman Sarit, Solar Irit, Fishman Sigal, Halpern Zamir, Sklan Ella H

Abstract excerpt

BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is strongly associated with insulin resistance and diabetes mellitus. Peroxisome proliferator-activated receptor-gamma co-activator 1α (PGC-1α) is a transcriptional co-activator involved in the initiation of gluconeogenesis in the liver. Increased hepatic expression of PGC-1α has been implicated in insulin resistance. We investigated whether modulation...

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Source

Identifiers

PMID: 22732512
DOI: 10.1016/j.jhep.2012.06.021

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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