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Article

Curcumin inhibits hepatitis B virus via down‐regulation of the metabolic coactivator PGC‐1α

29 Apr 2010

Abstract excerpt

Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1alpha, a...

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PMID: 20434445
DOI: 10.1016/j.febslet.2010.04.067

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