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Article

Hepatitis C virus infection: molecular pathways to metabolic syndrome.

Hepatology (Baltimore, Md.) - 1 Jun 2008

Sheikh Muhammad Y, Choi Jinah, Qadri Ishtiaq, Friedman Jacob E, Sanyal Arun J

Abstract excerpt

Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a genotype-dependent fashion, thus contributing to steatosis, progression of fibrosis and resistance to interferon therapy. The molecular mechanisms in genotype 1 patients that lead to metabolic syndrome are still ambiguous. Based on our current understanding, HCV proteins associate with mitochondria and endoplasmic reticulum and...

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Identifiers

PMID: 18446789
DOI: 10.1002/hep.22269

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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