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Induction of cancer cell stemness by chemotherapy

15 Jan 2012

Abstract excerpt

Recent studies indicate that cancer stem cells (CSCs) exist in most hematological and solid tumors. CSCs are characterized by their ability to self-renew and their capacity to differentiate into the multitude of cells that comprise the tumor mass. Moreover, these cells have been shown to be intrinsically resistant to conventional anticancer therapies. Despite their fundamental role in cancer pathogenesis, the...

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PMID: 22732500
DOI: 10.4161/cc.21021

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