Article
Evaluation of HIV-1 ambiguous nucleotide frequency during antiretroviral treatment interruption.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2012
Li Jonathan Z, Christensen Julie A, Wang Hongying, Spritzler John, Kuritzkes Daniel R
Abstract excerpt
Nucleotide mixtures in human immunodeficiency virus type 1 (HIV-1) population sequences reflect sequence diversity. We evaluated gag and pol ambiguous nucleotide frequencies during an analytic treatment interruption (ATI) in an HIV-1 therapeutic vaccine study. The proportion of ambiguous nucleotides was significantly higher at ATI week 16 than at either the time of first detectable viremia (P < 0.001 gag and P =...
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