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Article

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.

PloS one - 1 Jan 2012

Sareen Dhruv, Ebert Allison D, Heins Brittany M, McGivern Jered V, Ornelas Loren, Svendsen Clive N

Abstract excerpt

Spinal muscular atrophy (SMA) is a genetic disorder caused by a deletion of the survival motor neuron 1 gene leading to motor neuron loss, muscle atrophy, paralysis, and death. We show here that induced pluripotent stem cell (iPSC) lines generated from two Type I SMA subjects-one produced with lentiviral constructs and the second using a virus-free plasmid-based approach-recapitulate the disease phenotype and...

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Source

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Identifiers

PMID: 22723941
DOI: 10.1371/journal.pone.0039113
PMCID: PMC3378532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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