Article
Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis.
Molecular psychiatry - 1 Feb 2004
Sklar P, Pato M T, Kirby A, Petryshen T L, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares M J, Ferreira C P, Lei M, Verner A, Hudson T J, Morley C P, Kennedy J L, Azevedo M H, Lander E, Daly M J, Pato C N
Abstract excerpt
Schizophrenia is a common psychiatric disorder with a complex genetic etiology. To understand the genetic basis of this syndrome in Portuguese Island populations, we performed a genome-wide scan of 29 families with schizophrenia, which identified a single region on 5q31-5q35 with strong linkage (NPL=3.09, P=0.0012 at D5S820). Empirical simulations set a genome-wide threshold of NPL=3.10 for significant linkage....
Topics
- Azores
- Bipolar Disorder
- Chromosomes, Human, Pair 5
- Genetic Linkage
- Genetic Predisposition to Disease
- Genomics
- Humans
- Schizophrenia