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Article

Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13.

Molecular psychiatry - 1 Mar 2010

Francks C, Tozzi F, Farmer A, Vincent J B, Rujescu D, St Clair D, Muglia P

Abstract excerpt

Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case-control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent sharing within case-case pairs, relative to case-control or control-control pairs. The method is robust to allelic...

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PMID: 18794890
DOI: 10.1038/mp.2008.100

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