Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix.

Integrative biology : quantitative biosciences from nano to macro - 1 Aug 2012

Saha Sharmistha, Lo Pang-Kuo, Duan Xinrui, Chen Hexin, Wang Qian

Abstract excerpt

Cancer stem cells, also known as tumour-initiating cells (TICs), are identified as highly tumorigenic population within tumours and hypothesized to be main regulators in tumour growth, metastasis and relapse. Evidence also suggests that a tumour microenvironment plays a critical role in the development and progression of cancer, by constantly modulating cell-matrix interactions. Scientists have tried to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen

Share to Extracellular Matrix

Share to Fibronectins

Share to Laminin

Share to Mammary Neoplasms, Animal

Share to Neoplastic Stem Cells

Source

Identifiers

PMID: 22722498
DOI: 10.1039/c2ib20034a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix.PMID 22722498Read ↗

The biomimetic extracellular matrix: a therapeutic tool for breast cancer researchSemantic proximity Read ↗

The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assaySemantic proximity Read ↗

An In Vitro Approach to Model EMT in Breast Cancer.Semantic proximity Read ↗

Collagen and fibronectin promote an aggressive cancer phenotype in breast cancer cells but drive autonomous gene expression patterns.Semantic proximity Read ↗

Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.Semantic proximity Read ↗

Synergistic Cooperation Involving TGFβ1-mediated Crosstalk Enhances the Invasiveness of Genetically Distant Cancer Clones<strong></strong>Semantic proximity Read ↗

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions.Semantic proximity Read ↗

Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression.Semantic proximity Read ↗

Intratumoral phenotypic heterogeneity as an encourager of cancer invasion.Semantic proximity Read ↗

Breast cancer patient-derived scaffolds as a tool to monitor chemotherapy responses in human tumor microenvironments.Semantic proximity Read ↗

Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.