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Article

Breast cancer patient-derived scaffolds as a tool to monitor chemotherapy responses in human tumor microenvironments.

Journal of cellular physiology - 1 Jun 2021

Leiva Maria Carmen, Garre Elena, Gustafsson Anna, Svanström Andreas, Bogestål Yalda, Håkansson Joakim, Ståhlberg Anders, Landberg Göran

Abstract excerpt

Breast cancer is a heterogeneous disease where the tumor microenvironment, including extracellular components, plays a crucial role in tumor progression, potentially modulating treatment response. Different approaches have been used to develop three-dimensional models able to recapitulate the complexity of the extracellular matrix. Here, we use cell-free patient-derived scaffolds (PDSs) generated from breast...

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Identifiers

PMID: 33368325
DOI: 10.1002/jcp.30191
PMCID: PMC8049042

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