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Article

NOTCH1 signaling as a therapeutic target in Sézary syndrome.

The Journal of investigative dermatology - 1 Dec 2012

van der Fits Leslie, Qin Yongjun, Out-Luiting Jacoba J, Vermeer Kim G, Whittaker Sean, van Es Johan H, Tensen Cornelis P, Vermeer Maarten H

Abstract excerpt

NOTCH signaling is important for development and tissue homeostasis and is activated in many human cancers. We investigated a role for NOTCH1 signaling in Sézary syndrome (SS), a cutaneous T-cell lymphoma in which CD4+ tumor cells (Sézary cells) are present in the skin, lymph nodes, and peripheral blood. We show consistent expression of activated NOTCH1 by Sézary cells isolated from peripheral blood of SS...

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Source

Identifiers

PMID: 22718117
DOI: 10.1038/jid.2012.203

Genes

NOTCH1
HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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