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Article

Three routes to suppression of the neurodegenerative phenotypes caused by kinesin heavy chain mutations.

Genetics - 1 Sept 2012

Djagaeva Inna, Rose Debra J, Lim Angeline, Venter Chris E, Brendza Katherine M, Moua Pangkong, Saxton William M

Abstract excerpt

Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the occurrence of dystrophic axon terminals, reduced axonal transport, organelle-filled axonal...

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Identifiers

PMID: 22714410
DOI: 10.1534/genetics.112.140798
PMCID: PMC3430534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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