Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2

29 Sept 2009

Abstract excerpt

Genomic stability is constantly threatened by DNA damage, caused by numerous environmental and intrinsic sources, including radiation, chemicals and oncogene expression. Consequently, cells have evolved a sophisticated signal transduction network to sense DNA damage and to mount an appropriate DNA damage response. Dysregulation of the DNA damage response leads to genomic instability and cancer. Dependent on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19788416
DOI: 10.1111/j.1742-4658.2009.07331.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2PMID 19788416Read ↗

p53: DNA damage, DNA repair, and apoptosis.Semantic proximity Read ↗

Integrating the DNA damage and protein stress responses during cancer development and treatment.Semantic proximity Read ↗

Programs for Cell Death: Apoptosis is Only One Way to GoSemantic proximity Read ↗

DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunitiesSemantic proximity Read ↗

Activation of DNA damage response signaling in mammalian cells by ionizing radiationSemantic proximity Read ↗

p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseasesSemantic proximity Read ↗

Degradation‐linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti‐cancer therapySemantic proximity Read ↗

DNA damage responses and p53 in the aging processSemantic proximity Read ↗

Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).Semantic proximity Read ↗

P53: a determinant of the cell cycle response to DNA damage.Semantic proximity Read ↗

Complex Interplay between DNA Damage and Autophagy in Disease and TherapySemantic proximity Read ↗

The impact of p53 and p73 on aneuploidy and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.