Article
Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding.
The FEBS journal - 1 Apr 2008
Erbse Annette H, Wagner Judith N, Truscott Kaye N, Spall Sukhdeep K, Kirstein Janine, Zeth Kornelius, Turgay Kürsad, Mogk Axel, Bukau Bernd, Dougan David A
Abstract excerpt
Protein degradation in the cytosol of Escherichia coli is carried out by a variety of different proteolytic machines, including ClpAP. The ClpA component is a hexameric AAA+ (ATPase associated with various cellular activities) chaperone that utilizes the energy of ATP to control substrate recognition and unfolding. The precise role of the N-domains of ClpA in this process, however, remains elusive. Here, we have...
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