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Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

Free radical biology & medicine - 1 Oct 2012

Siddiqui Almas, Rivera-Sánchez Sulay, Castro María del R, Acevedo-Torres Karina, Rane Anand, Torres-Ramos Carlos A, Nicholls David G, Andersen Julie K, Ayala-Torres Sylvette

Abstract excerpt

Oxidative stress and mitochondrial dysfunction have been implicated in the pathology of HD; however, the precise mechanisms by which mutant huntingtin modulates levels of oxidative damage in turn resulting in mitochondrial dysfunction are not known. We hypothesize that mutant huntingtin increases...

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Identifiers

PMID: 22709585
DOI: 10.1016/j.freeradbiomed.2012.06.008
PMCID: PMC3846402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22709585-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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