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Article

Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis.

Experimental cell research - 15 Oct 2012

Jandova Jana, Janda Jaroslav, Sligh James E

Abstract excerpt

We previously reported the presence of a mtDNA mutation hotspot in UV-induced premalignant and malignant skin tumors in hairless mice. We have modeled this change (9821insA) in murine cybrid cells and demonstrated that this alteration in mtDNA associated with mtBALB haplotype can alter the biochemical characteristics of cybrids and subsequently can contribute to significant changes in their behavioral...

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Identifiers

PMID: 22705584
DOI: 10.1016/j.yexcr.2012.06.006
PMCID: PMC3418480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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