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High Yield Production Process for Shigella Outer Membrane Particles

6 Jun 2012

Abstract excerpt

Gram-negative bacteria naturally shed particles that consist of outer membrane lipids, outer membrane proteins, and soluble periplasmic components. These particles have been proposed for use as vaccines but the yield has been problematic. We developed a high yielding production process of genetically derived outer membrane particles from the human pathogen Shigella sonnei. Yields of approximately 100 milligrams...

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PMID: 22701551
DOI: 10.1371/journal.pone.0035616

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