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Article

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.

Cancer cell - 12 Jun 2012

Liu Wenjin, Monahan Kimberly B, Pfefferle Adam D, Shimamura Takeshi, Sorrentino Jessica, Chan Keefe T, Roadcap David W, Ollila David W, Thomas Nancy E, Castrillon Diego H, Miller C Ryan, Perou Charles M, Wong Kwok-Kin, Bear James E, Sharpless Norman E

Abstract excerpt

Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (±p53 loss) in murine melanocytes, we...

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Source

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Identifiers

PMID: 22698401
DOI: 10.1016/j.ccr.2012.03.048
PMCID: PMC3660964

Genes

STK11
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22698401-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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