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Article

Mouse as a model for multifactorial inheritance of neural tube defects.

Birth defects research. Part C, Embryo today : reviews - 1 Jun 2012

Zohn Irene E

Abstract excerpt

Neural tube defects (NTDs) such as spina bifida and anencephaly are some of the most common structural birth defects found in humans. These defects occur due to failures of neurulation, a process where the flat neural plate rolls into a tube. In spite of their prevalence, the causes of NTDs are poorly understood. The multifactorial threshold model best describes the pattern of inheritance of NTDs where multiple...

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Identifiers

PMID: 22692891
DOI: 10.1002/bdrc.21011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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