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Article

Mitochondrial ribosome and Ménière's disease: a pilot study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Aug 2012

Pacheu-Grau David, Pérez-Delgado Laura, Gómez-Díaz Covadonga, Fraile-Rodrigo Jesus, Montoya Julio, Ruiz-Pesini Eduardo

Abstract excerpt

Ménière's disease patients experience vestibular disability. When most of medical treatments fail, a chemical labyrinthectomy using aminoglycosides is indicated. However, this process frequently causes hearing damage. Aminoglycosides, interacting with mitochondrial rRNAs, alter mitochondrial protein synthesis and the oxidative phosphorylation system, which provide most of the energy in sensory hair cells. For...

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Source

Identifiers

PMID: 22692694
DOI: 10.1007/s00405-012-2066-8

Genes

MRPS12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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