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Article

Pediatric acute myeloid leukemia with t(8;21) and KIT mutation treatment with avapritinib post-stem cell transplantation: a report of four cases.

Annals of hematology - 1 Sept 2024

Wang Qingwei, Hu Yixin, Gao Li, Zhang Senlin, Lu Jun, Li Bohan, Li Jie, Yao Yanhua, Cheng Shengqin, Xiao Peifang, Hu Shaoyan

Abstract excerpt

Acute myeloid leukemia (AML) with t(8;21) (q22;q22), which forms RUNX1::RUNX1T1 fusion gene, is classified as a favorable-risk group. However, the presence of mutations in KIT exon 17 results in an adverse prognosis in this group. Avapritinib, a novel tyrosine kinase inhibitor, was designed to target KIT mutation. We report a retrospective study of four pediatric patients with AML with t(8:21) and KIT exon 17...

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Identifiers

PMID: 38802593
DOI: 10.1007/s00277-024-05810-z
PMCID: PMC11358162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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