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Article

JAK2 seems to be a typical cooperating mutation in therapy-related t(8;21)/ AML1-ETO-positive AML.

Leukemia - 1 Jan 2007

Schnittger S, Bacher U, Kern W, Haferlach C, Haferlach T

Abstract excerpt

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Share to Chromosomes, Human, Pair 21
Share to Chromosomes, Human, Pair 8
Share to Core Binding Factor Alpha 2 Subunit
Share to Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Second Primary

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 17096014
DOI: 10.1038/sj.leu.2404465

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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JAK2 seems to be a typical cooperating mutation in therapy-related t(8;21)/ AML1-ETO-positive AML.PMID 17096014Read ↗

Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/<i>AML1‐ETO</i>Semantic proximity Read ↗

AML with RUNX1::RUNX1T1 Cooperating two Mutations Relapsed Quickly after Achieving CR.Semantic proximity Read ↗

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.Semantic proximity Read ↗

AML1-ETO meets JAK2: clinical evidence for the two hit model of leukemogenesis from a myeloproliferative syndrome progressing to acute myeloid leukemia.Semantic proximity Read ↗

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Semantic proximity Read ↗

BCR-ABL1-positive and JAK2 V617F-positive clones in 23 patients with both aberrations reveal biologic and clinical importance.Semantic proximity Read ↗

Rare and novel RUNX1 fusions in myeloid neoplasms: A single-institute experience.Semantic proximity Read ↗

JAK2V617F as progression marker in CMPD and as cooperative mutation in AML with trisomy 8 and t(8;21): a comparative study on 1103 CMPD and 269 AML cases.Semantic proximity Read ↗

Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.Semantic proximity Read ↗

A JAK2-V617F activating mutation in addition to KIT and FLT3 mutations is associated with clinical outcome in patients with t(8;21)(q22;q22) acute myeloid leukemia.Semantic proximity Read ↗

Rare occurrence of the JAK1 mutation in acute promyelocytic leukemia patients.Semantic proximity Read ↗

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