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Article

Structural stability of human fibroblast growth factor-1 is essential for protective effects against radiation-induced intestinal damage.

International journal of radiation oncology, biology, physics - 1 Feb 2013

Nakayama Fumiaki, Umeda Sachiko, Yasuda Takeshi, Asada Masahiro, Motomura Kaori, Suzuki Masashi, Zakrzewska Malgorzata, Imamura Toru, Imai Takashi

Abstract excerpt

PURPOSE: Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable FGF1 mutants were created increasing stability in the order, wild-type FGF1, single mutants (Q40P, S47I, and H93G), Q40P/S47I, and Q40P/S47I/H93G. This study evaluated the contribution of the structural stability of FGF1 to its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22687193
DOI: 10.1016/j.ijrobp.2012.04.042

Genes

FGF1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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