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Article

A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family.

PloS one - 1 Jan 2012

Lee Yingying, Mick Jacob, Furdui Cristina, Beamer Lesa J

Abstract excerpt

Coevolution analyses identify residues that co-vary with each other during evolution, revealing sequence relationships unobservable from traditional multiple sequence alignments. Here we describe a coevolutionary analysis of phosphomannomutase/phosphoglucomutase (PMM/PGM), a widespread and diverse enzyme family involved in carbohydrate biosynthesis. Mutual information and graph theory were utilized to identify a...

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Identifiers

PMID: 22685552
DOI: 10.1371/journal.pone.0038114
PMCID: PMC3369874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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