Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Germline Mutation in <i>BAP1</i> Predisposes to Familial Clear-Cell Renal Cell Carcinoma

25 May 2013

Abstract excerpt

UNLABELLED: Renal cell carcinoma (RCC) clusters in some families. Familial RCC arises from mutations in several genes, including the von Hippel-Lindau (VHL) tumor suppressor, which is also mutated in sporadic RCC. However, a significant percentage of familial RCC remains unexplained. Recently, we discovered that the BRCA1-associated protein-1 (BAP1) gene is mutated in sporadic RCC. The BAP1 gene encodes a nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer Research and Treatments
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23709298
DOI: 10.1158/1541-7786.mcr-13-0111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Germline Mutation in <i>BAP1</i> Predisposes to Familial Clear-Cell Renal Cell CarcinomaPMID 23709298Read ↗

Germline BAP1 mutations predispose to renal cell carcinomas.Semantic proximity Read ↗

PBRM1 and BAP1 as novel targets for renal cell carcinoma.Semantic proximity Read ↗

BAP1 loss defines a new class of renal cell carcinoma.Semantic proximity Read ↗

Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art.Semantic proximity Read ↗

BAP1-Mutated Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

8q24 Clear Cell Renal Cell Carcinoma Germline Variant is Associated with VHL Mutation Status and Clinical AggressivenessSemantic proximity Read ↗

Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in SilicoSemantic proximity Read ↗

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer.Semantic proximity Read ↗

8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness.Semantic proximity Read ↗

A BAP1 Mutation-specific MicroRNA Signature Predicts Clinical Outcomes in Clear Cell Renal Cell Carcinoma Patients with Wild-type BAP1Semantic proximity Read ↗

BAP1: role in carcinogenesis and clinical implicationsSemantic proximity Read ↗

The expanding role of BAP1 in clear cell renal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.