Role of arginines in coenzyme A binding and catalysis by the phosphotransacetylase from Methanosarcina thermophila.

doi:10.1128/JB.183.14.4244-4250.2001

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Article

Role of arginines in coenzyme A binding and catalysis by the phosphotransacetylase from Methanosarcina thermophila.

Journal of bacteriology - 1 Jul 2001

Iyer P P, Ferry J G

Abstract excerpt

Phosphotransacetylase (EC 2.3.1.8) catalyzes the reversible transfer of the acetyl group from acetyl phosphate to coenzyme A (CoA): CH(3)COOPO(3)(2-) + CoASH <==> CH(3)COSCoA + HPO(4)(2-). The role of arginine residues was investigated for the phosphotransacetylase from Methanosarcina thermophila. Kinetic analysis of a suite of variants indicated that Arg 87 and Arg 133 interact with the substrate CoA. Arg 87...

Topics

Arginine
Catalysis
Coenzyme A
Diacetyl
Genetic Variation
Kinetics
Methanosarcina
Molecular Structure
Phosphate Acetyltransferase

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Identifiers

PMID: 11418565
DOI: 10.1128/JB.183.14.4244-4250.2001
PMCID: PMC95314

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