Article
Common pathological mechanisms in mouse models for muscular dystrophies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2006
Turk R, Sterrenburg E, van der Wees C G C, de Meijer E J, de Menezes R X, Groh S, Campbell K P, Noguchi S, van Ommen G J B, den Dunnen J T, 't Hoen P A C
Abstract excerpt
Duchenne/Becker and limb-girdle muscular dystrophies share clinical symptoms like muscle weakness and wasting but differ in clinical presentation and severity. To get a closer view on the differentiating molecular events responsible for the muscular dystrophies, we have carried out a comparative gene expression profiling of hindlimb muscles of the following mouse models: dystrophin-deficient (mdx, mdx(3cv)),...
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