Article
DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.
PLoS genetics - 1 Apr 2011
Schmidt Wolfgang M, Uddin Mohammed H, Dysek Sandra, Moser-Thier Karin, Pirker Christine, Höger Harald, Ambros Inge M, Ambros Peter F, Berger Walter, Bittner Reginald E
Abstract excerpt
Albeit genetically highly heterogeneous, muscular dystrophies (MDs) share a convergent pathology leading to muscle wasting accompanied by proliferation of fibrous and fatty tissue, suggesting a common MD-pathomechanism. Here we show that mutations in muscular dystrophy genes (Dmd, Dysf, Capn3, Large) lead to the spontaneous formation of skeletal muscle-derived malignant tumors in mice, presenting as mixed...
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