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Article

Cis-regulatory control of corticospinal system development and evolution.

Nature - 30 May 2012

Shim Sungbo, Kwan Kenneth Y, Li Mingfeng, Lefebvre Veronique, Sestan Nenad

Abstract excerpt

The co-emergence of a six-layered cerebral neocortex and its corticospinal output system is one of the evolutionary hallmarks of mammals. However, the genetic programs that underlie their development and evolution remain poorly understood. Here we identify a conserved non-exonic element (E4) that acts as a cortex-specific enhancer for the nearby gene Fezf2 (also known as Fezl and Zfp312), which is required for...

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Identifiers

PMID: 22678282
DOI: 10.1038/nature11094
PMCID: PMC3375921

Genes

SOX11
SOX4
SOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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