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Article

Variation in telangiectasia predisposing genes is associated with overall radiation toxicity.

International journal of radiation oncology, biology, physics - 15 Nov 2012

Tanteles George A, Murray Robert J S, Mills Jamie, Barwell Julian, Chakraborti Prabir, Chan Steve, Cheung Kwok-Leung, Ennis Dawn, Khurshid Nazish, Lambert Kelly, Machhar Rohan, Meisuria Mitul, Osman Ahmed, Peat Irene, Sahota Harjinder, Woodings Pamela, Talbot Christopher J, Symonds R Paul

Abstract excerpt

PURPOSE: In patients receiving radiotherapy for breast cancer where the heart is within the radiation field, cutaneous telangiectasiae could be a marker of potential radiation-induced heart disease. We hypothesized that single nucleotide polymorphisms (SNPs) in genes known to cause heritable telangiectasia-associated disorders could predispose to such late, normal tissue vascular damage. METHODS AND MATERIALS:...

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Identifiers

PMID: 22677372
DOI: 10.1016/j.ijrobp.2012.02.018

Genes

ATM
ACVRL1
ENG

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