Article
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012
Qi Wei, Chan HoMan, Teng Lin, Li Ling, Chuai Shannon, Zhang Ruipeng, Zeng Jue, Li Min, Fan Hong, Lin Ying, Gu Justin, Ardayfio Ophelia, Zhang Ji-Hu, Yan Xiaoxia, Fang Jialuo, Mi Yuan, Zhang Man, Zhou Tao, Feng Grace, Chen Zijun, Li Guobin, Yang Teddy, Zhao Kehao, Liu Xianghui, Yu Zhengtian, Lu Chris X, Atadja Peter, Li En
Abstract excerpt
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development. Recently, hot-spot mutations of Ezh2 were identified in diffused large B-cell lymphomas and follicular lymphomas. To investigate if tumor...
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