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Article

Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2012

Wentzensen Nicolas, Schwartz Lauren, Zuna Rosemary E, Smith Katie, Mathews Cara, Gold Michael A, Allen R Andy, Zhang Roy, Dunn S Terence, Walker Joan L, Schiffman Mark

Abstract excerpt

PURPOSE: Cytology-based screening has limited sensitivity to detect prevalent cervical precancers. Human papilloma virus (HPV) DNA testing is highly sensitive and provides a high, long-term reassurance of low risk of cervical cancer. However, the specificity of HPV DNA testing is limited, requiring additional, more disease-specific markers for efficient screening approaches. EXPERIMENTAL DESIGN: Liquid-based...

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Share to Colposcopy
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human papillomavirus 16

Share to Ki-67 Antigen

Share to Neoplasms, Squamous Cell

Share to Referral and Consultation

Share to Uterine Cervical Dysplasia

Share to Vaginal Smears

Source

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Identifiers

PMID: 22675168
DOI: 10.1158/1078-0432.CCR-12-0270
PMCID: PMC4237612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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