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Article

Epigenetic and gene expression changes related to transgenerational carcinogenesis

19 Apr 2004

Abstract excerpt

Transgenerational carcinogenesis refers to transmission of cancer risk to the untreated progeny of parents exposed to carcinogens before mating. Accumulated evidence suggests that the mechanism of this process is epigenetic, and might involve hormonal and gene expression changes in offspring. To begin to test this hypothesis, we utilized a mouse model (NIH Swiss) in which exposure of fathers to Cr(III) chloride 2...

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PMID: 15108325
DOI: 10.1002/mc.20022

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