Article
Midline crossing is not required for subsequent pathfinding decisions in commissural neurons.
Neural development - 6 Jun 2012
Bonner Jennifer, Letko Michael, Nikolaus Oliver Brant, Krug Lisa, Cooper Alexandria, Chadwick Benjamin, Conklin Phoebe, Lim Amy, Chien Chi-Bin, Dorsky Richard I
Abstract excerpt
BACKGROUND: Growth cone navigation across the vertebrate midline is critical in the establishment of nervous system connectivity. While midline crossing is achieved through coordinated signaling of attractive and repulsive cues, this has never been demonstrated at the single cell level. Further, though growth cone responsiveness to guidance cues changes after crossing the midline, it is unclear whether midline...
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