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Article

Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon.

Mechanisms of development - 1 Jul 2012

Hofmeister Wolfgang, Devine Christine A, Rothnagel Joseph A, Key Brian

Abstract excerpt

The anterior commissure forms the first axon connections between the two sides of the embryonic telencephalon. We investigated the role of the transmembrane receptor Frizzled-3a in the development of this commissure using zebrafish as an experimental model. Knock down of Frizzled-3a resulted in complete loss of the anterior commissure. This defect was accompanied by a loss of the glial bridge, expansion of the...

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PMID: 22609481
DOI: 10.1016/j.mod.2012.05.004

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Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon.PMID 22609481Read ↗

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