Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.

doi:10.1042/BSR20120050

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Article

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.

Bioscience reports - 1 Aug 2012

Yuen Hiu-Fung, Abramczyk Olga, Montgomery Grant, Chan Ka-Kui, Huang Yu-Han, Sasazuki Takehiko, Shirasawa Senji, Gopesh Srivastava, Chan Kwok-Wah, Fennell Dean, Janne Pasi, El-Tanani Mohamed, Murray James T

Abstract excerpt

Inhibition of the PI3K (phosphoinositide 3-kinase)/Akt/mTORC1 (mammalian target of rapamycin complex 1) and Ras/MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK pathways for cancer therapy has been pursued for over a decade with limited success. Emerging data have indicated that only discrete subsets of cancer patients have favourable responses to these...

Topics

Apoptosis
Benzamides
Cell Line, Tumor
Cell Survival
Drug Synergism
Feedback, Physiological
Furans
Humans
MAP Kinase Signaling System
Mechanistic Target of Rapamycin Complex 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Multiprotein Complexes

Mutation

Okadaic Acid

Oncogenes

Phosphatidylinositol 3-Kinases

Phosphoinositide-3 Kinase Inhibitors

Phosphoprotein Phosphatases

Source

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Identifiers

PMID: 22668349
DOI: 10.1042/BSR20120050
PMCID: PMC3392104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22668349-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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